Study shows how skin cancer hijacks the immune system to grow and spread

Study Shows How Skin Cancer Hijacks The Immune System To Grow And Spread paper is one like the Health and Medical Updates groups, published during our author Linda Norton just after January 31, 2019, that section probably want to search with the tags cancer, grow, hijacks, immune, shows, Skin, spread, Study, system. I am happy to blissful you and providing those anothers article attributed health as well I'm always publishing this article daily.

Skin Cancer 620x480.jpg

Scientists have uncovered molecules released by invasive skin cancer that reprogram healthy immune cells to help the cancer to spread.

Targeting these molecules with inhibiting drugs could help to prevent this aggressive skin cancer coming back after treatment.

The findings of the Cancer Research UK-funded study are published in Cell, today (Thursday).

Researchers from Queen Mary University of London looked at cells from the edges of invasive melanomas in mice and human tumor samples, to investigate the effects of a protein they produce – called Myosin II.

They found that high levels of Myosin II in these cells not only makes them more mobile, but also triggers the release of chemicals that reprogram the immune system.

These chemicals affect the surrounding healthy immune cells, called macrophages, and hijack their natural cancer-killing abilities. This means that instead of attacking the cancer cells, they end up helping them to survive.

Some of these chemicals also make tiny holes in the blood vessels, allowing cancer cells to escape into the bloodstream and to new areas of the body.

Professor Vicky Sanz-Moreno, Cancer Research UK-funded lead author from Barts Cancer Institute, Queen Mary University of London, said:

This study highlights how cancer cells interact with and influence their surrounding environment to grow and spread. Developing treatments that target the chemicals that alter the immune system could help to prevent the spread of the disease.”

Researchers also found that one of the chemicals released by Myosin II-rich cells, called interleukin 1A, was key for making cancer cells more invasive. By blocking Myosin II activity with different drugs, they reduced the amount of interleukin 1A produced by melanoma cells in mice and human tumor samples.

Professor Sanz-Moreno explains:

By using therapeutic drugs that block either Myosin II activity or the release of interleukin 1A, we can make the tumor less invasive and slow its growth, making it easier to treat.”

Drugs that block Myosin II activity are already being used to treat diseases such as glaucoma, a progressive disease of the eye. Researchers are planning further lab studies to investigate whether drugs that block Myosin II could be combined with existing melanoma treatments.

Sanz-Moreno add:

We are excited to find out whether inhibitor drugs could be used in combination with other targeted therapies. By identifying effective treatment combinations, we hope that in the future Myosin II and interleukin 1A inhibitors could be used to improve patient outcomes and reduce the risk of melanoma coming back.”

Professor Richard Marais, director of the Cancer Research UK Manchester Institute and melanoma expert, said:

These exciting findings show how the basic research that Cancer Research UK funds is helping us to understand cancer biology and develop effective treatments for cancer patients.


When melanoma is removed, there’s always a chance that some cells could remain. What this study shows is that we may be able to develop treatments to stop those remaining cells from spreading after surgery, helping patients to survive for longer.”

Source:

https://www.cancerresearchuk.org/about-us/cancer-news/press-release/2019-01-31-skin-cancer-can-spread-in-mice-by-hijacking-the-immune-system

You can gather other paper health at our linked chapter or you maybe want to checkup immediately upon well-received part, we always posting those health paper frequenlty for advise as well clue plus gift in order to manage our health along with living these healthy lifestyle. The part is published on top of Linda Norton with those title Study Shows How Skin Cancer Hijacks The Immune System To Grow And Spread.

Related posts of "Study shows how skin cancer hijacks the immune system to grow and spread"

Two-thirds of filers cite illness and medical bills as contributors to financial ruin

Medical problems contributed to 66.5% of all bankruptcies, a figure that is virtually unchanged since before the passage of the Affordable Care Act (ACA), according to a study published yesterday as an editorial in the American Journal of Public Health. The findings indicate that 530,000 families suffer bankruptcies each year that are linked to illness...

New research findings could be key to improving outcomes for some brain cancers

IDH1-mutant glioma increases tumor cells' DNA damage response, reducing the efficacy of radiation treatment. Delivering a DNA damage repair inhibitor made the tumors sensitive to radiation treatment. Credit: Ella Marushchenko, art-director/illustrator and Alexander Tokarev, PhD from Ella Maru Studio Researchers from the University of Michigan Rogel Cancer Center have found that a genetic mutation seen...

Exposure to chemicals before and after birth is associated with a decrease in lung function

Credit: CC0 Public Domain A study co-directed by the Barcelona Institute for Global Health (ISGlobal) and the French Institute for Health and Biomedical Research (INSERM), in collaboration with other European teams, concludes that early life exposure to parabens, phthalates and perfluoroalkyl substances (PFAS) is associated with reduced lung function in children. The study, published in...

Normal brain aging patterns occur at a faster rate in people with psychosis

This graph depicts group differences in network efficiency. Specifically, patients with psychosis showed significantly reduced global efficiency in the frontoparietal and subcortical networks, in comparison to healthy controls. Credit: Elsevier Patients with psychosis have accelerated aging of two brain networks important for general cognition—the frontoparietal network (FPN) and cingulo-opercular network (CON)—according to a new study...

Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.